Notes Feb 3 - Feb 3 Lecture 5 Today and next time pp 848-...

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Feb 3 Lecture 5 Today and next time pp 848- 865 Next time Ch 24 section 5 pg 883-890 Fig 3.36; 3-6; 3-7; 3-4,5,8; Fig 24-16, box 24-2, 24-18,19,20; 24-23; Table 24-2; 24-21 pA pU pC pG pA p II U p II C p II G II= cut Chargaff rules - %G=%C; %A=%T - Different DNAs from different species had different G+C % content DNA Structure - Unstable for bases to be exposed to the water - Stable for sugar and phosphate are hydrophilic and to be exposed to the water - Base pairs are in the interior - Right handed coiling - Very regular structure in distance o Base pairs have the same geometry o Major and minor groove Proteins that recognize specific DNA sequences, some proteins recognizes bases in the major groove or bases in the minor group - Eq favors the enol form which is crucial for base pairing - Two fold symmetry of the structure o Suggested that it was a double strand structure and was antiparallel o Right away from the structure, watson and crick guesses its double stranded structure o Turns repreated after every 34A, the distance between successive base pairs was 3.4A
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Notes Feb 3 - Feb 3 Lecture 5 Today and next time pp 848-...

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