BioE+10+-+device+1+-+theory+-+part+1

BioE+10+-+device+1+-+theory+-+part+1 - Device #1...

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BioE 10 – UC Berkeley Bioengineering Click to edit Master subtitle style Device #1 Genetically engineered yeast
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BioE 10 – UC Berkeley Bioengineering Click to edit Master subtitle style Problem Production of the anti-malarial drug artemisinin
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BioE 10 – UC Berkeley Bioengineering Malaria Caused by  Plasmodium , a single- celled protozoan Transmitted by Anopheles mosquito ~106 killed each year 90% of the victims are children Thought to be a profound selective  pressure in recent human evolution Plasmodium sporozoite traversing the cytoplasm of a mosquito cell
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BioE 10 – UC Berkeley Bioengineering Treatment and prevention Current Medication (treatment  or prophylaxis) Mosquito population  control Mosquito netting Vaccination Engineered malaria- resistant mosquitoes
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BioE 10 – UC Berkeley Bioengineering Medication Prophylactics Mefloquine Doxycycline Atovaquone Proguanil Quinine Treatments Chloroquine Amodiaquine Mefloquine Primaquine Artemisinin Halofantrine
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BioE 10 – UC Berkeley Bioengineering Why the need for so many treatments? Four species of  plasmodium cause  malaria Efficacy of a given  treatment is species- specific Drug resistance can  develop over time
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BioE 10 – UC Berkeley Bioengineering Artemisinin Typically isolated  from the plant  Artemisia annua  (sweet wormwood) Used by Chinese  herbalists as early as  200 BC
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BioE 10 – UC Berkeley Bioengineering Sweet wormwood One ton or 100 acres  worth of leaves  required to produce  6kg of artemisinin Purification by hexane  extraction; acetonitrile  fractionation
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BioE 10 – UC Berkeley Bioengineering Click to edit Master subtitle style Solution Genetically engineered yeast
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BioE+10+-+device+1+-+theory+-+part+1 - Device #1...

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