question2 - Normal Process by which E. Coli produces...

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Normal Process by which E. Coli produces isoprenoids: Two Isoprenoid biosynthetic pathways exist that synthesize two key precursors of artemisinin: isopentenyl pyrophosphate (IPP), and its isomer dimethylallyl pyrophosphate (DMAPP). Eukaryotes other than plants use only the mevalonate-dependent (MEV) isoprenoid pathway to convert acetyl-CoA to IPP. Plants use both the MEV and the mevalonate-independent (deoxyxylulose 5-phosphate-DXP) pathway. Prokaryotes use the DXP pathway to produce IPP and DMAPP separately through a branch point. The use of the DXP pathway in E. Coli has proven to be ineffective in producing isoprenoids. However, genetic introduction of MEV pathway genes (along with a synthetic amorphadiene synthase gene) as an alternative to the E. Coli DXP pathway has resulted in a biosynthetically useful method for production of artemisinin. Figure 1
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Alternative Process: There are two basic pathways by which artemisinin is produced: the mevalonate (MEV) pathway in eukaryotes and the deoxyxylulose 5-phosphate (DXP) pathway in prokaryotes. Dr Keasling
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This note was uploaded on 09/15/2011 for the course CH 53492 taught by Professor Ellington during the Spring '11 term at University of Texas at Austin.

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question2 - Normal Process by which E. Coli produces...

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