question1 - Relevant Papers: 1. Bond-Watts, B. B., R. J....

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The Pathway Drawn: Both of the pathways used by the researchers at Berkeley and Arkansas utilize acetyl-CoA. The acetyl-CoA is produced by creating biomass which is rich in carbohydrate, then utilizing the carbohydrate through glycolysis to make pyruvate, which is then used to make acetyl-CoA (via pyruvate dehydrogenase).1 2 3 Figure 1.1: Overview of Glycolysis (from Fundamentals of Biochemistry, Wiley, 1999)4 The pyruvate produced is then used to generate acetyl-CoA as shown in figure 1.2:
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Figure 1.2: from Lehninger Prin. of Biochemistry (2008). Reaction catalyzed by PDH.5 The final set of reactions generating butanol are engineered into the target organism. The enzymes in various the various steps are from Clostridium beijerinckii, E. coli, S. cerevisiae, and others.2
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Figure 1.3: Pathway to butanol production (from Steen(2008)).2
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Unformatted text preview: Relevant Papers: 1. Bond-Watts, B. B., R. J. Bellerose, et al. (2011). "Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways." Nat Chem Biol 7(4): 222-227. DOI:doi:10.1038/nchembio.537 2. Steen, E., R. Chan, et al. (2008). "Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol." Microbial Cell Factories 7(1): 36. 3. Hestekin, J. The production of butanol fuel from renewable systems using a membrane assisted fermentation system, MBTC DOT-3018 4. Voet, D.; Voet, J. G.; Pratt, C. W., Fundamentals of Biochemistry. John Wiley & Sons: New York, 1999. 5. Cox, M.; Nelson, D., Lehninger Principles of Biochemistry. 5th ed.; W.H. Freeman and Company: New York, 2008....
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question1 - Relevant Papers: 1. Bond-Watts, B. B., R. J....

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