GI_tumor_markers - Soluble chemical markers of...

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Soluble chemical markers of Soluble chemical markers of gastrointestinal and pancreatic gastrointestinal and pancreatic tumors tumors Roger L. Bertholf, Ph.D. Roger L. Bertholf, Ph.D. Associate Professor of Pathology Associate Professor of Pathology University of Florida Health Science Center/Jacksonville University of Florida Health Science Center/Jacksonville
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Leading causes of death in the United States Total Deaths Deaths per 100,000 All causes 2,312,203 880 Cardiovascular disease 738,781 281 Cancer 537,969 205 Cerebrovascular 158,061 60 COPD 104,756 40 Accidents 89,703 34 Source: http://www.cdc.gov (1995 data)
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Causes of cancer deaths in the United States Site Males Females Lifetime risk Lung 91,405 54,538 1:12 to 1:19 Prostate 34,240 1:5 Breast 43,068 1:8 Colon/rectum 28,434 28,942 1:16 Pancreas 12,672 13,399 Source: CA Cancer J Clin 46:1996
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Incidence and mortality of GI/pancreatic tumors (1996 estimates) Site New Cases Deaths Colon/rectum 133,500 (10%) 57,100 (9%) Pancreas 26,300 (2%) 27,800 (5%) Stomach 22,800 (2%) 14,000 (3%) Small intestine 4,600 1,140 Source: CA Cancer J Clin 46:1996
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Colorectal cancer Vast majority of cases are adenocarcinomas Begins with adenomatous polyps Molecular biology Point mutations in ras proto-oncogene on chromosome 12 p53 deletion (chromosome 17) “DCC” gene deletion (chromosome 18) “MCC” gene mutation (chromosome 5) “APC” gene mutation (chromosome 5)
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This note was uploaded on 09/18/2011 for the course MED 6566 taught by Professor Staff during the Summer '11 term at University of Florida.

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GI_tumor_markers - Soluble chemical markers of...

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