thyroid - Thyroid Roger L. Bertholf, Ph.D. Associate...

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Thyroid Roger L. Bertholf, Ph.D. Associate Professor of Pathology Director of Clinical Chemistry & Toxicology
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Thyroid hormones O OH CH 2 HC NH 3 + COO - I I I I O OH CH 2 HC NH 3 + COO - I I I O OH CH 2 HC NH 3 + COO - I I I Tetraiodothyronine (T 4 , Thyroxine) 3,5,3´ Triiodothyronine (T 3 ) 3,3´,5´ Triiodothyronine (reverse T 3 )
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Effects of thyroid hormones • Calorigenic ( O 2 consumption) Growth, development, sexual maturation, CNS maturation 2200 HR and contraction 2200 Protein synthesis, C(H 2 O) n metabolism, lipid turnover 2200 Sensitivity of β -adrenergic receptors to catecholamines Brain, retina, lungs, spleen, testes appear to be unaffected by thyroid hormones
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TRH TSH T 4 (T 3 ) T 3 (rT 3 ) Regulation of thyroid hormones
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Thyroid hormone production T 1 T 2 Thyroglobulin T 4 T 3 Thyroglobulin T 3 T 4 Thyroglobulin Iodide ( I- ) NIS* T 4 T 4 T 4 TBG Alb TBPA I- Colloid Follicle TPO TSH (40X) *Sodium/Iodide Symporter protein
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Thyroid hormone synthesis OH CH 2 I - OH CH 2 I I O CH 2 OH I I I I O CH 2 OH I I I I HOOC NH 2 Tyrosyl residue Thyroglobulin protease TPO TPO Thyroglobulin Free thyroxine
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Peripheral T 4 metabolism CH 2 HOOC NH 2 O OH I I I CH 2 HOOC NH 2 O OH I I I I T 4 T 3 CH 2 HOOC NH 2 O OH I I I 5 ' -(3 ' -) Deiodinase Type I or II reverse T 3 5-(3-) Deiodinase Three types 40% 45%
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Peripheral thyroxine metabolism • T 4 production is exclusively thyroidal • 70-90% of T
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thyroid - Thyroid Roger L. Bertholf, Ph.D. Associate...

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