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ETSslides - Electron Transport and Oxidative...

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Electron Transport and Oxidative Phosphorylation *Introduction* stage 3 of respiration NADH & FADH oxidized, electrons are “carried” (ETS) energy in form of ATP (Ox/Phos) aerobic acceptor = oxygen
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Mitochondrion -- A. football shaped (1-2 μ ), 1-1000s in each cell B. electron transport and oxidative phosphorylation Cytosol
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C. Outer membrane - permeable to small molecules D. Inner membrane - electron transport enzymes embedded; also ATP synthase Cristae increase area Impermeable to small molecules Integrity required for coupling ETS to ATP synthesis Cytosol
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E. Matrix TCA enzymes, other enzymes; also ATP, ADP, NAD + , NADH, Mg 2+ , etc.
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The Electron Transport System is the mechanism the cell uses to convert the energy in NADH and FADH 2 into ATP. Electrons flow along an energy gradient via carriers in one direction from a higher reducing potential (greater tendency to donate electrons) to a lower reducing potential (greater tendency to accept electrons). The ultimate acceptor is molecular oxygen.
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-- The overall voltage drop from NADH E  = -(-0.32 V) to O = +0.82 V is = 1.14 V
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-- This corresponds to a large free energy change of G  = - n F E  = -220 kJ/mole (n =2) -- Since ATP requires 30.5 kJ/mole to form from ADP, more than enough energy is available to synthesize 3 ATPs from the oxidation of NADH.
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NADH Dehydrogenase- Complex I NADH-CoQ oxidoreductase Contains FMN/FMNH 2 and an Iron Sulfur Center as Electron Carriers NADH is substrate Coenzyme Q is second substrate
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NAD + /NADH NADP + /NADPH Never covalently bound- freely diffusible Nicotinamide
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Flavin mononucleotide = FMN Flavin adenine dinucleotide = FAD Riboflavin = ring + ribitol i soalloxazine ring ribitol
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2H + +2e Coenzyme Q Coenzyme Q Coenzyme Q = Ubiquinone a lipid in inner membrane carries electrons polyisoprene tail moves freely within membrane CoQ CoQH 2 (reduced form)
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