proteins - Instructor Robert Cohen ARB R3-206B Office Hours...

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Instructor: Robert Cohen ARB R3-206B Office Hours: MTWF 3-4pm Phone: 392-4050 Email: [email protected] Website: www.med.ufl.edu/biochem/rcohen/rcohen.html
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Reading in Alberts et al (5th edition) Lecture Reading 1,2 52-54, 59-60, 109 3,4 63-64, 110-11, 125-148, 152- 158,1184-1191 5,6 61-62, 116-17, 195-199, 211- 219, 368-369, 419-426 7,8 72-75, 158-169, 211 9,10 169-181, 893-897, 904-909, 919- 920, 66-68, 70-72, 75-78, 80-86, 118-119
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MACROMOLECULES OF LIFE NUCLEIC ACIDS - - later POLYSACCHARIDES - - later PROTEINS - - discussed now 1. Enzymes are the catalysts of life. They are involved in synthesis and degradation. Very specific in reaction catalyzed and substrate. Greatly speeds up reactions. Many are targets of drug therapy.
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2. structural proteins are the supports. Examples: keratin - epithelia cells - - skin, nails, feathers, etc.
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collagen - major insoluble extracellular matrix protein also in connective tissue — rope-like, rigid, withstand stretching
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elastin - gives elasticity to lung, arteries, etc. --allows stretch and recoil
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tubulin —part of the cytoskeleton within cells microtubules in 3T3 cells tubulin
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3. storage proteins hold onto metabolites, oxygen, or metal ions until needed. Examples: lipoproteins hold lipids myoglobin oxygen ferritin Fe zein amino acids
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4. transport proteins bind and carry molecules. Examples: -hemoglobin carries oxygen -lipoproteins also deliver lipids -albumin delivers fatty acids and drugs -some transport molecules through membranes. These include amino acids, peptides, K + , Na + , Cl - , H + ,glucose
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5. contraction proteins are involving in providing movement. All need energy Example: Actomyosin In muscle also cell motility
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6. Glycoproteins contain sugar groups Examples: Mucin, bacterial cell wall, cell membrane ( plasmamembrane) proteins 7. Defensive proteins protect Examples: Antibodies, venoms
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Antibodies -- defensive proteins in blood. Y- shaped. Two identical heavy subunits and two identical light subunits Variable regions called CDRs bind specific antigens. Flu viral protein CDR light heavy
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8. Receptors receive and transmit signals a) plasmamembrane-bound - receive instructions for the cell - some bind to specific molecules and activate a pathway. Examples: - some hormones = epinephrine, ACTH, human growth hormone, insulin - cellular factors, neurotransmitters, olfactants
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b) intracellular membrane-bound receptors including those containing a chromophore to absorb light: Examples: rhodopsin, cryptochrome, chlorophyll complex c) soluble protein receptors such as steroid receptors
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10. Precursor proteins are medium-sized proteins processed to yield active hormones and factors. Example: pro-opiomelanocortin (POMC) POMC ACTH, melanocyte stimulating hormone, β-lipotropin, ß-endorphin, etc
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AMINO ACIDS A. Basic structure side chain R carboxyl - O-C - C - NH 3 + primary amine O H -carbon B. Zwitterion at physiological pH. (most)
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C. Chiral asymmetry - OOC - OOC down L D up + H 3 N C H H C NH 3 + R R Only L form is found in proteins (exc. gly)
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D. Classification -those found in proteins - according to side chain: nonpolar (hydrophobic), polar, uncharged acidic basic
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ala val leu ile pro met phe trp nonpolar -CH 3
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gly ser asn gln thr cys tyr polar, uncharged
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asp glu acidic
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basic lys arg his
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This note was uploaded on 09/18/2011 for the course BCH 4024 taught by Professor Allison during the Spring '08 term at University of Florida.

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proteins - Instructor Robert Cohen ARB R3-206B Office Hours...

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