Nano-micro-topography-Jager-JBB-2007 - Hindawi Publishing...

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Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2007, Article ID 69036, 19 pages doi:10.1155/2007/69036 Review Article Signifcance oF Nano- and Microtopography For Cell-SurFace Interactions in Orthopaedic Implants M. J ¨ager, 1 C. Zilkens, 1 K. Zanger, 2 and R. Krauspe 1 1 Department of Orthopaedics, Heinrich-Heine University Medical School, Moorenstrasse 5, 40225 Duesseldorf, Germany 2 Institute of Anatomy II, Heinrich-Heine University Medical School, Universit¨atsstrasse 1, 40225 Duesseldorf, Germany CorrespondenceshouldbeaddressedtoM.J¨ager, Received 18 March 2007; Accepted 5 August 2007 Recommended by Hicham Fenniri Cell-surface interactions play a crucial role for biomaterial application in orthopaedics. It is evident that not only the chemical composition of solid substances in±uence cellular adherence, migration, proliferation and di f erentiation but also the surface to- pography of a biomaterial. The progressive application of nanostructured surfaces in medicine has gained increasing interest to improve the cytocompatibility and osteointegration of orthopaedic implants. Therefore, the understanding of cell-surface inter- actions is of major interest for these substances. In this review, we elucidate the principle mechanisms of nano- and microscale cell-surface interactions in vitro for di f erent cell types onto typical orthopaedic biomaterials such as titanium (Ti), cobalt-chrome- molybdenum (CoCrMo) alloys, stainless steel (SS), as well as synthetic polymers (UHMWPE, XLPE, PEEK, PLLA). In addition, e f ects of nano- and microscaled particles and their signi²cance in orthopaedics were reviewed. The signi²cance for the cytocom- patibility of nanobiomaterials is discussed critically. Copyright © 2007 M. J¨ager et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. INTRODUCTION Nanobiomaterials are characterized by constituent particles and/or surface features less than 100 nm in at least one di- mension [1]. Starting with photolithography and dry etch- ing in the 1980’s to high-resolution electron beam lithogra- phy and other technologies in the 1990’s, nanotechnology al- lows for making surface structures for cell engineering and has led to an increasing application in healthcare over the last decades. Nanolayers are used to enhance the surface biocompati- bility of polymeric drug delivery systems, control the release of substances such as antibiotics or growth factors [2], act as gene-delivery vehicles, or serve as robust light emitters for cellular labeling and tracking [semiconductor nanocrystals, quantum dots (QDs)] [3]. Nanotechnology is also applied to modify and improve the surface structure in orthopaedic im- plants to promote their osseous integration.
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Nano-micro-topography-Jager-JBB-2007 - Hindawi Publishing...

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