BIS 104 quiz 2 key SS II 2011 (edwards)

BIS 104 quiz 2 key SS II 2011 (edwards) - QUIZ #2 key 1....

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QUIZ #2 key 1. SCID mice were injected with LNCaP cells expressing either normal α 5 β 3 integrins or mutated S752P integrins. The tumors that grew from these injections were then fixed, sectioned, immunohistochemically stained for CD31, and then examined by bright-field light microscopy. The CD31 staining pattern in the α 5 β 3 tumors was compared to that of the S752P tumors. a. What is CD31? (2 pts) A marker for endothelial cells. b. State the specific HYPOTHESIS that is tested by this experiment. (4 pts) The activation state of tumor integrin α 5 β 3 controls tumor growth through the regulation of angiogenesis. 2. Cells with a mutated gene coding for the enzyme desaturase A (desA) fail to proliferate when cultured at 22 o C but grow at a normal rate at 31 o C. (6 pts) Design one EXPERIMENT to test the hypothesis that providing cells with a functional desaturase A gene would be sufficient to restore their ability to proliferate at a normal rate at 22 o C. List the steps of your
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BIS 104 quiz 2 key SS II 2011 (edwards) - QUIZ #2 key 1....

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