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Lecture 6-2nots

Lecture 6-2nots - Kidney 10/6 Kidney summary What we’ve...

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Unformatted text preview: Kidney 10/6 Kidney: summary What we’ve lear ned so far • Urine formation by filtration • Functional unit = nephron – Bowman’s capsule: where filtration occurs – Proximal tubule • Absorbs ~2/3 of NaCl, water • Absorbs glucose • Secretes organic cations and anions Proximal tubule Fluid exiting proximal tubule has 1/3 the volume Same π , C NaCl 3x higher conc of inert solutes <3x higher conc glucose >3x higher conc bile salt, epinephrine Sherwood Klandorf Yancey Fig. 12-8 (detail) Nephron What we’ve lear ned so far • Bowman’s capsule: where filtration occurs • Proximal tubule • Loop of Henle – Descends further into the medulla in organisms that make hyperosmotic urine (juxtamedullary nephrons) Juxtamedullary nephron • Mammals which make more concentrated urine (desert mammals) – Have higher medullary volume – Have higher π serosa in medulla Sherwood Klandorf Yancey Fig. 12-29 Nephron What we’ve lear ned so far • Bowman’s capsule: where filtration occurs • Proximal tubule • Loop of Henle – Descending limb: thin, no brush border • Passive loss of water, NaCl • Loses water because π serosa is high • Hyperosmotic urine! Loop of Henle • Descending limb – P Na , P Cl low =>no absorption or secretion – P high=>filtrate comes to osmotic equilibrium with serosa . π = 300 Sherwood Klandorf Yancey Fig. 12-27 (detail) Nephron • Bowman’s capsule: where filtration occurs • Proximal tubule • Loop of Henle – Descending limb: thin, no brush border – Ascending limb: • Thin, no brush border Loop of Henle • Ascending limb, lower – Thin: no brush border – Rises to region of lower external...
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Lecture 6-2nots - Kidney 10/6 Kidney summary What we’ve...

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