anesthetics_Anna_final

anesthetics_Anna_final - nesthetics and mechanisms of...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: nesthetics and mechanisms of general anesthesia Anna Kuznetsova Volatile anesthetics And Elemental noble gases: He, Ar Morton 1846 Anesthetics are a mainstay of modern medicine, but their molecular mechanism f action is still not known Anesthetics are structurally very different and have weak affinity for their targets However, the mechanism will provide the key to making the perfect anesthetic! http://www.doctorspiller.com/local_anesthetics_4.htm Nerve impulse is the key to sensation Synapse- contact between nerve cells i m p u l s e impulse http://www.doctorspiller.com/local_anesthetics_4.htm Depolarisation process for impulse generation and conductance Resting potential Depolarization (impulse) 1. Inhibiting the depolarization by reducing the influ x of sodium ions into cytoplasm so that threshold necessary for sensation is not reached Threshold of sensitivity Current theory suggests anesthetics block impulse by: 2. decreasing resting potential (hyperpolarization) by increase K + conductance of membrane or increasing Cl- conductance To affect ion channels, the anesthetic molecules must actually enter membrane of the nerve. And herein lies the difference in the potency, time of onset and duration of the various anesthetics. his correlation is accurate for a broad range of general anesthetics:alkanols, volatile gents, and barbiturates. Also, volatile anesthetics are generally additive in their ffects: a mixture of a half dose of two different volatile anesthetics was in fact equal to a full dose of either drug in isolation....
View Full Document

Page1 / 15

anesthetics_Anna_final - nesthetics and mechanisms of...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online