Cardiolipin - Cardiolipin Xi Huang Feb 3, 2009 Cardiolipin...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Cardiolipin Xi Huang Feb 3, 2009
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cardiolipin Structure Biosynthesis and metabolism Function Cardiolipin in disease
Background image of page 2
Diphosphatidylglycerol 1,3- bis ( sn -3’-phosphatidyl)- sn -glycerol It’s usually found in certain membrane of bacteria and of mitochondria. It amounts to about 10% of the phospholipids of bovine heart muscle, and 20% of the phospholipids of the mitochondrial membrane in this organ Structure of Cardiolipin
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Structure of Cardiolipin ____________________________________________________________________________ Schlame, M., Brody, S. and Hostetler, K.Y. Eur. J. Biochem (2002) 528 35-39
Background image of page 4
Acyl chain - 18:2 In heart mitochondria pK 1 ≈3, pK 2 X 7.5 Acid-anion bicyclic resonance structure One of the protons is trapped ____________________________________________________________________________ Thomas H. Hainesa;, Norbert A. Dencherb. (2002) FEBS Letters 528 35-39 N 10-N-Nonyl acridine NAO
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Biosynthesis and metabolism Eukaryotic mechanism Prokaryotic mechanism
Background image of page 6
Biosynthesis and metabolism PLA2 PLA2 PLD PLD
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/19/2011 for the course CHM 6304 taught by Professor Richards during the Fall '08 term at University of Florida.

Page1 / 14

Cardiolipin - Cardiolipin Xi Huang Feb 3, 2009 Cardiolipin...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online