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9/19/11
Cell Penetrating Peptides
William Hardy
Biomembranes: Structure and Biophysical Properties
University of Florida
Spring 2009
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Introduction
Cell Penetrating Principles
Mechanisms
Specific Pathways
Specific Applications
Conclusion
Questions
References
Outline
9/19/11
Short polycationic or amphiphilic peptides which
facilitate cellular uptake of various molecular cargo
linked to them either in a covalent or non-covalent
fashion.
What are Cell Penetrating
Peptides ?
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The first CPP was discovered independently by
two laboratories in 1988
It was found that the trans-activating
transcriptional activator (Tat) from Human
Immunodeficiency Virus 1 (HIV-1) could be
efficiently taken up from the surrounding media by
numerous cell types in culture.
History
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Most peptide- and nucleic acid-based drugs are
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- Fall '08
- RICHARDS
- pH, Master subtitle style, Cell Penetrating Peptides, Int. J. Mol., J. Mol. Sci., various molecular cargo, Cell Penetrating Peptides
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