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Cell Penetrating Peptides[1]

Cell Penetrating Peptides[1] - WilliamHardy Biomembranes:...

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Click to edit Master subtitle style  9/19/11 Cell Penetrating Peptides William Hardy Biomembranes: Structure and Biophysical Properties University of Florida Spring 2009
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 9/19/11 Introduction Cell Penetrating Principles Mechanisms Specific Pathways Specific Applications Conclusion Questions References  Outline
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 9/19/11 Short polycationic or amphiphilic peptides which  facilitate cellular uptake of various molecular cargo  linked to them either in a covalent or non-covalent  fashion.  What are Cell Penetrating  Peptides ?
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 9/19/11 The first CPP was discovered independently by  two laboratories in 1988  It was found that the trans-activating  transcriptional activator (Tat) from Human  Immunodeficiency Virus 1 (HIV-1) could be  efficiently taken up from the surrounding media by  numerous cell types in culture. History
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 9/19/11 Most peptide- and nucleic acid-based drugs are 
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  • Fall '08
  • RICHARDS
  • pH, Master subtitle style, Cell Penetrating  Peptides, Int. J. Mol., J. Mol. Sci., various molecular cargo, Cell Penetrating Peptides

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