lecture11 - 40s 70s 50s Membrane Rafts Membrane...

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Membrane Rafts ‘70s ‘40s ‘50s
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Membrane Microdomains Raft is a specific type of microdomain – sphingolipid/cholesterol rich region “Separation of discrete liquid-ordered and liquid-disordered phase domains occurring with sufficient amounts of cholesterol” Microdomain formation is believed to be involved in following cellular processes: •Cell sorting •Signal transduction •Endocytosis •Calcium homeostasis •And others Rafts: liquid ordered domain – lipids are fluid in that they have a high degree of lateral diffusion, but the acyl chains are closed packed and ordered. Glycosphingolipids (particularly sphingolmyelin and glycosylphosphoinositol- GPI anchored proteins preferentially partition into rafts.)
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Origin: TritonX 100 insoluble components isolated from biological membranes: Detergent Resistant Membranes DRM. Does DRM always equal a “raft”
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This note was uploaded on 09/19/2011 for the course CHM 6304 taught by Professor Richards during the Fall '08 term at University of Florida.

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lecture11 - 40s 70s 50s Membrane Rafts Membrane...

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