lecture16 - Chapter 5 of Yeagle Structure of Biological...

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Chapter 5 of Yeagle Structure of Biological Membranes •Non-lamellar phases •Spontaneous curvature •Actual curvature What is the physical basis of non-lamellar phase structures? Can we understand the competing forces that stabilize a lamellar versus a non-lamellar phase? Bilayer thickness Surface charge Dielectric constant Lipid composition In cells, primarily lamellar structures are found, yet lipids extracted from cells will form non-lamellar phases in vitro.
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•POLYMORPHISM •MESOMORPHISM
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General Motivation: (1) by studying structural polymorphism/mesomorphism, one gaines an understanding of the forces that are “locked-up” in biomembranes that can affect the organization and function of membrane proteins (2) Generally extended to surfactant/detergent chemistry This chapter is interested in phase changes that change the CURVATURE of the lipid-water interface. These phases occur at temperatures above the gel-liquid transition, but below the transition temperature to an isotropic liquid.
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Why do we care about CURVATURE?
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