lecture18 - Membrane Fusion Chapter 8 of Yeagle. Majority...

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Membrane Fusion Chapter 8 of Yeagle. Majority of work is taken from papers by B. Lentz at UNCCH (Biochemistry) Membrane fusion is ubiquitous and critical process in biology : •Cellular trafficking and compartmentalization •Import of food •Export of waste •Intracellular communication •Sexual reproduction •Cell division •Viral fusion
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Protein Mediated
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tubes Lipid segregation Fission/fusion Lipid mixing
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Mechanisms of Membrane Fusion: Fusion Pore is made of (A) protein and lipid, (B) lipid only (B) Is the accepted pathway, this does not imply proteins are NOT involved. Proteins are involved, but they do not line the fusion Pore
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Detailed molecular mechanism is still unclear for fusion. Secretory Vesicles and Viral Fusion Today: Focus just on the lipids and bilayer fusion without the aid of proteins. Research of the last 15 years has shown a close association between membrane fusion and inverted phase formation. Both T
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lecture18 - Membrane Fusion Chapter 8 of Yeagle. Majority...

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