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lecture20 - Hydrophobic Mismatch Lateral Pressure These...

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Unformatted text preview: Hydrophobic Mismatch Lateral Pressure These lecture notes are taken from current literature. See special edition of BBA, (biomembranes) 1666 2004. Our previous lectures have discussed in detail what is meant by “non- bilayer” structures (really non-lamellar because inverted hexagonal phase is somewhat bilayer in nature). This figure reviews how shape is related to mesophase. Effects of “non-bilayer” lipids on membrane proteins: • Curvature Stress – discussed in detail in previous lectures • Hydrophobic mismatch • Packing Defects • Lateral Pressure Profiles Our Motivation : To understand how lipids and lipid-protein interactions drive membrane protein function and membrane-protein interactions Different types of “membrane” proteins Hydrophobic Mismatch When the hydrophobic region of a protein or peptide (length) differs from that of the bilayer, the bilayer will adapt and curve to “cover” the hydrophobic surface area of the protein....
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lecture20 - Hydrophobic Mismatch Lateral Pressure These...

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