8-28-08 - Advanced Biochemistry and Chemical Biology...

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Unformatted text preview: Advanced Biochemistry and Chemical Biology CHM4034 Spring 2008 Dr. Lyons office hours lyons@chem.ufl.edu 846-3392- W 10-11 AM- T,R 4:00-5:00 PM Class website http://www.chem.ufl.edu/~lyons/ Monosaccharides are modified Monosaccharides are modified Aldonic Acid C C C C C CH 2 OH O H OH OH H H OH H H HO C C C C C CH 2 OH O OH OH OH H H OH H H HO C C C C C C O H OH OH H H OH H H HO O OH Aldose Uronic Acid Glucose Gluconic Acid Glucuronic Acid Oxidation reduction reactions : The aldehyde moiety in aldoses can be oxidize to yield a carboxylic acid, the resulting compounds are known as aldonic acids. Monosaccharides are modified C C C C C H O H OH OH H H OH H OH H C C C C C H OH OH H H OH H OH H OH H H Ribose Ribitol- The reduction of the carbonyl group in aldoses and ketoses yields polyols known as alditols CH 2 OH CH 2 OH OH H Glycerol H OH OH H H OH H OH OH OH H H Inositol Nucleic Acids The Ultimate Building Blocks N N N H N NH 2 Purines N N N N NH 2 O X OH H H H H O P-O O- O N N N N NH 2 O X OH H H H H HO Adenosine NUCLEOSIDE Adenosine monophosphate NUCLEOTIDE Adenine BASE Deoxyadenosine DEOXYNUCLEOSIDE Deoxyadenosine monophosphate DEOXYNUCLEOTIDE NH N N H N O NH 2 Purines NH N N O NH 2 N O X H H H H OH O P-O O O- NH N N O NH 2 N O X H H H H OH HO Guanine BASE Guanosine NUCLEOSIDE Guanosine monophosphate NUCLEOTIDE Deoxyguanosine DEOXYNUCLEOSIDE Deoxyguanosine monophosphate DEOXYNUCLEOTIDE N N H NH 2 O Pyrimidines N NH 2 O N O X OH H H H H O P-O O- O N NH 2 O N O X OH H H H H HO Cytosine BASE Cytidine NUCLEOSIDE Cytidine monophosphate NUCLEOTIDE Deoxycytidine DEOXYNUCLEOSIDE Deoxycytidine monophosphate DEOXYNUCLEOTIDE Pyrimidines (DNA only) NH N H O O NH O O N O H OH H H H H O P-O O- O NH O O N O H OH H H H H HO Thymine BASE Thymidine NUCLEOSIDE Thymidine monophosphate NUCLEOTIDE Deoxythymidine DEOXYNUCLEOSIDE Deoxythymidine monophosphate DEOXYNUCLEOTIDE Pyrimidines (RNA only) Uracil BASE Uridine NUCLEOSIDE Uridine Monophosphate NUCLEOTIDE NH N H O O NH O O N O OH OH H H H H O P-O O- O NH O O N O OH OH H H H H HO N N N N NH 2 O OH OH H H H H O P O O- O P-O O O- N N N N NH 2 O OH OH H H H H O P-O O- O N N N N NH 2 O OH OH H H H H O P O O- O P O O O- P O-O O- Nucleotide monphosphate Nucleotide diphosphate Nucleotide triphosphate AMP/dAMP ADP/dADP ATP/dATP Base Nucleoside Deoxy Nucleoside Nucleotide Deoxy Nucleotide Adenine A Adenosine A Deoxyadenosine dA Adenosine mono, di, triphosphate AMP, ADP, ATP Deoxyadenosine mono, di, triphosphate dAMP, dADP, dATP Thymine T Thymidine T Deoxythymidine dT Thymidine mono, di, triphosphate TMP, TDP, TTP Deoxythymidine mono, di, triphosphate dTMP, dTDP, dTTP Cytosine C Cytidine C Deoxycytidine dC Cytidine mono, di, triphosphate CMP, CDP, CTP Deoxycytidine mono, di, triphosphate dCMP, dCDP, dCTP Guanine G Guanosine G Deoxyguanosine dG Guanosine mono, di, triphosphate GMP, GDP, GTP Deoxyguanosine mono, di, triphosphate dAMP, dADP, dATP Uracil U Uridine U Deoxyuridine dU Uridine mono, di, triphosphate UMP, UDP, UTP Deoxyuridine mono, di, triphosphate dUMP, dUDP, dUTP Signaling nucleotides...
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This note was uploaded on 09/20/2011 for the course CHM 4034 taught by Professor Staff during the Summer '11 term at University of Florida.

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8-28-08 - Advanced Biochemistry and Chemical Biology...

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