- Tryptophan Cysteine is degraded by 2 pathways(1 Oxidation by cysteine dioxygenase His Fe2 His OH2 His H OH2 H His H2O His S OH2 Fe2 His-O CH2 O

Info iconThis preview shows pages 1–19. Sign up to view the full content.

View Full Document Right Arrow Icon
Tryptophan
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cysteine is degraded by 2 pathways (1) Oxidation by cysteine dioxygenase H C C NH 3 + CH 2 S H His Fe 2+ His His OH 2 OH 2 O - O H 2 O H C C NH 3 + CH 2 S H O O - + O 2 H C C NH 3 + CH 2 S H His 2+ His His O O O - O H C C NH 3 + CH 2 S H His 3+ His His O - O O - O B H C C NH 3 + CH 2 S His Fe 2+ His His -O O O - O H C C NH 3 + CH 2 S + His 2+ His His O 2- O O - O H C C NH 3 + CH 2 S His 2+ His His O - O O - O H C COO - NH 3 + CH 2 SO 2 - Cysteinesulfinate His Fe 2+ His His OH 2 H 2 O
Background image of page 4
H C COO - NH 3 + CH 2 SO 2 - α-κετογ λυταρατε γ λυταμ ατε - ΟΟΧ Χ Ο ΧΗ 2 Σ Ο - Η Ο Η Β - Χ Ο - ΧΗ 2 ΣΟ 3 2- Η Α - Χ Ο ΧΗ 3
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
So…Cys = pyruvate + NH 3 If: Pyruvate = 4 NADH + GTP + FADH 2 Then: Cys = 4 NADH + GTP + FADH 2 + NH 3 If GTP = ATP NADH = 3 ATP FADH 2 = 2 ATP H 3 = -2 ATP Then: Cys = 13 ATP However…. .
Background image of page 6
(2) Cysteine desulfurylase: looks like serine dehydratase H C COO - NH 3 + CH 2 SH N H + O - 2- O 3 PO C H O Schiff Base Formation H C COO - NH + CH 2 SH N H + O - 2- O 3 PO C H B H A H 2 S C COO - NH + N H + O - 2- O 3 PO C H CH 2 Schiff Base Hydrolysis C COO - NH 2 N H + O - 2- O 3 PO C H CH 2 O
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cys = 1 pyruvate + NH 3 + H 2 S - OOC NH 2 H+ - OOC NH 2 CH 3 Schiff Base Hydrolysis - O CH 3
Background image of page 8
Pyruvate + NH 3 + ATP + NADPH ---> alanine + ADP + P i + NADP +
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Methionine
Background image of page 10
O - O O CH 3 + N C - H+ O - O OH CH 3 C + N 3 C N O R O - O H+ + N C O 3 R COO - H B O 3 R -
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 12
O CH 3 O R COO - H B H+ OH CH 3 O COO - R H- H+ 3 - R H Acetohydroxyacid isomeroreductase
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 14
OH CH 3 OH COO - R H B H+ CH 3 O COO - R H B H+ 3 O - R H
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Citrate synthase Aconitase IDH
Background image of page 16
Pyruvate + α -ketobutyrate + 2 NADPH + NH 3 + ATP ---> Isoleucine + 2NADP + + ADP + P i 2Pyruvate + 2 NADPH + NH 3 + ATP ---> valine + 2NADP + + ADP + P i 2Pyruvate + 2 NADPH + NH 3 + ATP + Acetyl-CoA + NAD + ---> leucine + 2NADP + + NADH + ADP + P i
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Degradation of branched chain amino acids Valine, leucine and isoleucine First three steps are shared H C COO - NH 3 + CH R 1 R 2 N H + 2- O 3 PO O - C H Schiff Base Formation H C COO - NH + CH R 1 R 2 N H + 2- O 3 PO O - C
Background image of page 18
Image of page 19
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/20/2011 for the course CHM 4034 taught by Professor Staff during the Summer '11 term at University of Florida.

Page1 / 91

- Tryptophan Cysteine is degraded by 2 pathways(1 Oxidation by cysteine dioxygenase His Fe2 His OH2 His H OH2 H His H2O His S OH2 Fe2 His-O CH2 O

This preview shows document pages 1 - 19. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online