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10-14-08 - Tryptophan Cysteine is degraded by 2 pathways(1...

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Tryptophan
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Cysteine is degraded by 2 pathways (1) Oxidation by cysteine dioxygenase H C C NH 3 + CH 2 S H His Fe 2+ His His OH 2 OH 2 O - O H 2 O H C C NH 3 + CH 2 S H O O - + O 2 H C C NH 3 + CH 2 S H His Fe 2+ His His O O O - O H C C NH 3 + CH 2 S H His Fe 3+ His His O - O O - O B H C C NH 3 + CH 2 S His Fe 2+ His His -O O O - O H C C NH 3 + CH 2 S + His Fe 2+ His His O 2- O O - O H C C NH 3 + CH 2 S His Fe 2+ His His O - O O - O H C COO - NH 3 + CH 2 SO 2 - Cysteinesulfinate His Fe 2+ His His OH 2 H 2 O
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H C COO - NH 3 + CH 2 SO 2 - α-κετογ λυταρατε γ λυταμ ατε - ΟΟΧ Χ Ο ΧΗ 2 Σ Ο Ο - Η Ο Η Β - ΟΟΧ Χ Ο - ΧΗ 2 ΣΟ 3 2- Η Α - ΟΟΧ Χ Ο ΧΗ 3
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So…Cys = pyruvate + NH 3 If: Pyruvate = 4 NADH + GTP + FADH 2 Then: Cys = 4 NADH + GTP + FADH 2 + NH 3 If GTP = ATP NADH = 3 ATP FADH 2 = 2 ATP H 3 = -2 ATP Then: Cys = 13 ATP However…..
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(2) Cysteine desulfurylase: looks like serine dehydratase H C COO - NH 3 + CH 2 SH N H + O - 2- O 3 PO C H O Schiff Base Formation H C COO - NH + CH 2 SH N H + O - 2- O 3 PO C H B H A H 2 S C COO - NH + N H + O - 2- O 3 PO C H CH 2 Schiff Base Hydrolysis C COO - NH 2 N H + O - 2- O 3 PO C H CH 2 O
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Cys = 1 pyruvate + NH 3 + H 2 S - OOC NH 2 H+ - OOC NH 2 CH 3 Schiff Base Hydrolysis - OOC O CH 3
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Pyruvate + NH 3 + ATP + NADPH ---> alanine + ADP + P i + NADP +
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Methionine
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O - O O CH 3 + N C - H+ O - O OH CH 3 C + N OH CH 3 C N O R O - O H+ + N C O CH 3 OH R COO - H B O CH 3 OH R COO -
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O CH 3 O R COO - H B H+ OH CH 3 O COO - R H- H+ OH CH 3 OH COO - R H Acetohydroxyacid isomeroreductase
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OH CH 3 OH COO - R H B H+ CH 3 O COO - R H B H+ CH 3 O COO - R H
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Citrate synthase Aconitase IDH
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Pyruvate + α -ketobutyrate + 2 NADPH + NH 3 + ATP ---> Isoleucine + 2NADP + + ADP + P i 2Pyruvate + 2 NADPH + NH 3 + ATP ---> valine + 2NADP + + ADP + P i 2Pyruvate + 2 NADPH + NH 3 + ATP + Acetyl-CoA + NAD + ---> leucine + 2NADP + + NADH + ADP + P i
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Degradation of branched chain amino acids Valine, leucine and isoleucine First three steps are shared H C COO - NH 3 + CH R 1 R 2 N H + 2- O 3
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