10-16-08 - 3Glucose-6-P 3Ru5P F6P E4P R5P Gln NH3 3PG 2 PEP...

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3Glucose-6-P 3Ru5P F6P + E4P + R5P 2 PEP + E4P + R5P 3PG Serine Tryptophan + pyruvate + GAP + CO 2 Gln NH 3 + + +
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Aldolase
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H O H O COO - H O OH OH CH 2 OPO 3 2- CH 2 HO OH OH CH 2 OPO 3 2- H O COO - P O - O - O B 2-keto-3-deoxy-arabinoheptulosonate-7-phosphate synthase
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CH 2 HO OH OH CH 2 OPO 3 2- H O COO - O O COO - OH OH 2- O 3 PO H B H NAD+ O COO - OH 2- O 3 PO O B H O - O H- H+ O - HO
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O COO - O OH HO H B O COO - O OH CH 2 - HO H+ - O HO
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chorismate synthase COO - 2- O 3 PO OH O R N N NH N O O H H R B COO - OH O R N N NH N O O H R - O R N N NH N O R H H - O R N H N NH N O O R H+ H B
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COO - OH O COO - Chorismate - OOC O COO - OH Prephenate Phenylalanine Tyrosine COO - OH p-hydroxybenzoate Coenzyme Q MeO MeO O O Me R COO - NH 2 p-aminobenzoate Tetrahydrofolate COO - NH 2 Anthranilate Tryptophan Nictotinamide
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COO - OH O COO - NH 2 O R E S H B H+ O E R OH- H+ NH 3 - O O R H NH 2 B H+ COO - O - NH 2 H B H+ - NH 2 Pyruvate +
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Ribose-5-phosphate Cost = 2 ATP
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N OH OH O COO - 2- O 3 PO H B H+ N OH COO - 2- O 3 PO H HN - 2- O 3
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NH O O - HO OH H OH H CH 2 OPO 3 2- H H+ N H + O O - OH CH 2 OPO 3 2- OH H H N H HO CH 2 3 2- H H H B H+ N H CH 2 3 2- H H
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N CH 2 OPO 3 2- OH H OH H H B H+ N CH 2 OPO 3 2- OH H O H H B H+ N H O H CH 2 3 2-
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3 glucose + 5NADP + + 2NAD + + 2ATP serine + glutamine ---> Tryptophan + 5NADPH + 2NADH + 2ADP + 2P i + GAP + pyruvate + 4CO 2 + glutamate GAP + glutamate + ATP + 2NADH = serine glutamine costs NADPH + 2NH 4 + + 2ATP 3 glucose + 4NADP + + 2NH 4 + + 4NAD + + ADP + P i ---> Tryptophan + 4NADPH + 4NADH + ATP + pyruvate + 4CO 2
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COO - OH O C CH 2 COO - OH - OOC H 2 C C O COO - Chorismate mutase
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C O COO - OH C O COO - O O - O - OOC O COO - OH O - O H+ O COO - OH H+ O - prephenate
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3 glucose + 2NAD + + 4NADP + + NH 4 + + ATP ---> phenylalanine + R5P + 4NADPH + 2NADH + 4CO 2 + ADP + P i 3 glucose + 3NAD + + 4NADP + + NH 4 + + ATP ---> tyrosine + R5P + 4NADPH + 3NADH + 4CO 2 + ADP + P i In animals tyrosine is made from phenylalanine by phenylalanine hydroxylase
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10-16-08 - 3Glucose-6-P 3Ru5P F6P E4P R5P Gln NH3 3PG 2 PEP...

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