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10-30-08 - OH2 His OH2 O2 Fe2 His O O O His H2N His His-O N...

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His Fe 2+ His O OH 2 OH 2 O HO H 2 N COO - O 2 O O His Fe 2+ His O - O H O N H 2 COO - O - O His Fe 3+ His O - O H O N H 2 COO - O - O His Fe 2+ His O - O H O N H 2 + COO - O - O His Fe 2+ His O - O O N H 2 + COO - H B O - O His Fe 2+ His O - O O N H 2 + COO - His Fe 2+ His O - O O O - OOC N H 2 O - H H+ H B 2-amino-3- carboxymuconate-6- semialdehyde 3-hydroxyanthranilate dioxygenase
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O O - OOC N H - O H H A N H COO - COO - HO H H B H A N COO - COO - If you need nictotinamide it ends here
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O O - OOC H 2 N - O H N COO - COO - Non-enzymatic N H + C O NH 2 2-amino-3-carboxymuconate semialdehyde dehydrogenase Mechanism and cofactor completely unknown NAD + - OOC O NH 2 - OOC O NH 2 COO - = Further degradation Assume loss of NADH
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- OOC O NH 2 H C O C O O - NH 2 N + C O H S H E B H C O - C O O - NH 2 S E C O C O O - NH 2 S E N C O H R - O H B C O C O O - NH 2 - O H A 2-aminomuconate NADH NAD +
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C O C O O - NH 2 - O 2-aminomuconate O H B A H C O C O O - NH 2 - O O H H B A H - O O O O - O N C H 2 N O R H H H A - O O O O - O N + C H 2 N O R NADP + NADPH α-κετοαδιπατε Trp = 12 ATP - 2 NADPH - (NADH?) + NADH + α -ketoadipate + NH 3 + NH 3
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CH 2 CH 2 C O COO - S C - N + X Y R S C N + X Y R C CH 2 CH 2 O - C O - O S C N X Y R C CH 2 CH 2 O - CO 2 S S H A S C N + X Y R C CH 2 CH 2 O - HS S S C - N + X Y R C CH 2 CH 2 O HS S H S CoA B H 2 C CH 2 C O S CoA HS S - Glutaryl-CoA CH 2 COO - CH 2 COO - CH 2 COO - CH 2 COO - CH 2 COO - CH 2 - OOC α -ketoadipate dehydrogenase Same mechanism as pyruvate dehydrogenase and α -ketoglutarate dehydrogenase.
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S S - H N + C O NH 2 S S N C O NH 2 α -ketoadipate = NADH + glutaryl-CoA
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CH CH C O S CoA Glutaryl-CoA CH 2 - OOC H H B N N NH N R O O H A N H N NH H N R O O FAD FADH 2 C C C O S CoA CH
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