Atherosclerosis - Atherosclerosis Lipoprotein and...

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Atherosclerosis Lipoprotein and Cholesterol Metabolism DEN 5121 Charles M. Allen Office: R3-226B Phone: 392-3366 email: callen@biochem.med.ufl.edu
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Atherosclerosis is a disease where artery walls become less elastic and thicker with fatty materials accumulating beneath the inner lining of an arterial wall. People who have high blood pressure, are cigarette smokers or diabetics and those having high levels of cholesterol are at greater risk of developing this disease. Prevention of this disease is aided by eliminating the controllable risk factors.
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Relationship Between Plasma Cholesterol Levels and Death
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When atherosclerosis begins, monocytes will migrate from the blood stream into the wall of the artery (sometimes a site of wall injury). They are then transformed into macrophage that ingest oxidized LDL that contains cholesterol. In time this results in a patchy thickening called plaque. This plaque accumulates in the inner lining of the artery as a soft cheese like substance (fatty streaks). Smooth muscle cells and connective tissue from underlying areas gradually move into this area resulting in a thickening of the wall (formation of atheromas).
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Arteries affected with atherosclerosis tend to loose their elasticity, the thickening continues resulting in a narrowing the arteries.
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This note was uploaded on 09/20/2011 for the course BCH 4024 taught by Professor Allison during the Fall '08 term at University of Florida.

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Atherosclerosis - Atherosclerosis Lipoprotein and...

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