Complexcarbohydrates

Complexcarbohydrates - Complex Carbohydrates: Roles in...

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Complex Carbohydrates: Roles in Cellular Health and Disease DEN 5121 Charles M. Allen Office: R3-226B Phone: 392-3366 email: [email protected]
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Glycoproteins Proteoglycans Peptidoglycans
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Glycoproteins Structure Biosynthesis Function
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Overview of the secretory pathway
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Electron Micrograph Showing Detailed Structure
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Cytosolic transmembrane protein biosynthesis Figure 17-22
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Different structures characterize N - and O -linked oligosaccharides N -linked oligosaccharides, complex O -linked oligosaccharides
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Precursors in the synthesis of oligosaccharides are nucleoside diphosphate or monophosphate sugars
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Sugars are transferred by specific glycosyltransferases
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N-Linked Glycoprotein Biosynthesis
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A common preformed N-linked oligosaccharide is added to nacent proteins in the rough ER
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Oligosaccharide Transfer and Processing in the Rough ER Figure 17-36
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Modifications to N -linked oligosaccharides are completed in theGolgi complex Oligosaccharides may promote folding and stability of glycoproteins
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O-Linked Glycoprotein Synthesis
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ABO blood type is determined by two glycosyl- transferases ( or protein )
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This note was uploaded on 09/20/2011 for the course BCH 4024 taught by Professor Allison during the Fall '08 term at University of Florida.

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Complexcarbohydrates - Complex Carbohydrates: Roles in...

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