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Unformatted text preview: Figure 1. A schematic diagram of the structure of the influenza A virus particle. Three types of integral membrane protein hemagglutinin (HA), neuraminidase (NA), and small amounts of the M2 ion channel proteinare inserted through the lipid bilayer of the viral membrane. The virion matrix protein M1 is thought to underlie the lipid bilayer but also to interact with the helical ribonucleoproteins (RNPs). Within the envelope are eight segments of single-stranded genome RNA (ranging from 2341 to 890 nucleotides) contained in the form of an RNP. Associated with the RNPs are small amounts of the transcriptase complex, consisting of the proteins PB1, PB2, and PA. The coding assignment of the eight RNA segments are also illustrated. RNA segments 7 and 8 each code for more than one protein (M1 and M2, and NS1 and NS2, respectively). NS1 is found only in infected cells and is not thought to be a structural component of the virus, but small amounts of NS2 are present in purified virions....
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- Fall '08