Nucleotide Metabolism

Nucleotide Metabolism - and Salvage Ribonucleotide...

Info iconThis preview shows pages 1–13. Sign up to view the full content.

View Full Document Right Arrow Icon
Nucleotide Metabolism DEN 5121 Charles M. Allen Office: R3-226B Phone: 392-3366 email: [email protected]
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Pathway for Pyrimidine Biosynthesis phosphoribosyl PP
Background image of page 2
Biosynthesis of dTMP
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
phosphoribosyl PP + _ Regulation of Pyrimidine Biosynthesis in Mammals Carbamyl phosphate synthetase II is • inhibited by UTP • activated by PRPP
Background image of page 4
Purine Biosynthesis
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Regulation of Purine Biosynthesis
Background image of page 6
Purine Degradation and Salvage hypoxanthine guanine Hypoxanthine guanine phosphoribosyl transferase (HGPRT)
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Abnormalities in Degradation
Background image of page 8
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 10
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 12
Background image of page 13
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: and Salvage Ribonucleotide Reductase Regulation of Ribonucleotide Reductase Antimetabolites That Effect Purine and Pyrimidine Metabolism Inhibit folate reductases Folic acid analogues Inhibits ribonucleotide reductase Cytosine arabinoside 5- Fluorouracil Inhibits synthesis of dTTP Biosynthesis of dTMP _ _ Methotrexate, aminopterin Inhibit folate reductases 5- Fluorouracil _ Folic acid HIV Inhibitors AZT ddC ddI dHT Inhibits Reverse Transcriptase Inhibit Replication of DNA...
View Full Document

This note was uploaded on 09/20/2011 for the course BCH 4024 taught by Professor Allison during the Fall '08 term at University of Florida.

Page1 / 13

Nucleotide Metabolism - and Salvage Ribonucleotide...

This preview shows document pages 1 - 13. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online