Prostaglandin - Eicosinoid Metabolism DEN 5121 Charles M...

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Eicosinoid Metabolism DEN 5121 Charles M. Allen Office: R3-226B Phone: 392-3366 email: [email protected]
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Lipid Anabolism (Biosynthesis) Fatty acids Cholesterol ACETYL CoA Prostaglandins, Thromboxanes Leucotrienes Phospholipids Triglycerides Sphingolipids HMG CoA Steroids Bile Acids Vit D
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Structures of Prostaglandins
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Arachidonic acid is a common precursor to all prostaglandins.
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Functions of the Prostaglandins PGI , PGE, PGD Increases Decreases Vasodilation Platelet aggregation cAMP Leukocyte aggregation IL-1 and IL-2 T- Cell proliferation Lymphocyte migration PGF Increases Vasoconstriction Bronchoconstriction Smooth muscle contraction
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Functions of Thromboxane A 2 (TXA 2 ) Increases Vasoconstriction Platelet aggregation Lymphocyte proliferation Bronchoconstriction
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Consequences of Production of PGI and TXB 2 on Vasculature and Platelet Aggregation PGI (prostacyclin) produced by endothelial cells promotes vascular dilation and decreases platelet aggregation. •T X B 2 (thromboxane) produced by platelets promotes vascular constriction and platelet aggregation.
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Prostaglandin - Eicosinoid Metabolism DEN 5121 Charles M...

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