Chapter 15

Chapter 15 - Chapter15 SpecificImmunity 0...

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Chapter 15 Specific Defenses of the Host Specific Immunity 0 •When the non-specific defense fails, then the third, specific line of  immunity is activated 1 •Immunity is not innate but adaptive; acquired over time 2 •It is characterized with a specificity and memory 0 –Specificity - antibodies against chickenpox is not effective against  measles virus 1 –During 2nd encounter with a pathogen, the lymphocytes recall the 1st  engagement and attacks it again Immunity 3 •Defensive response of the body when a foreign organism or foreign  substance invades it 4 Antigens  are substances (proteins or polysaccharides) that provoke  immune response 5 Antibodies  are proteins produced to inactivate the antigens 6 •During immune response, the lymphocytes recognize and bind to the  antigen 7 8 2 components 0 Humoral immunity  - production of antibodies (B-cells) 1 Cell-mediated immunity  - activation and proliferation of immune system  cells (t-cells) Lymphocytes 9 Overview of Lymphocyte Development and Interaction (5 stages)     0 1. Development of B-cells and t-cells 1 2. Antigen presenting cells present the antigen to lymphocytes 2 3. Lymphocytes proliferate - produce responder cells and memory cell 3 4. B lymphocytes become plasma cell - produce antibodies 4 5. Activated T-cells become Helper T-cells and cytotoxic T cells 10 11 Specificity of the Lymphocytes
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0 •They have receptor sites on the cell surface that can recognize  millions of different antigens 1 •This great diversity of receptor sites is achieved through genetic  recombination of 500 genes 2 •The lymphocytes with the receptor sites for “self” cells are eliminated 3 •Upon entry of an antigen only lymphocytes specific to that antigen  proliferate - clonal selection 1 Antigens 0 –Characteristics 0 •Not a normal constituent of the body
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This note was uploaded on 09/16/2011 for the course MCB 2000 taught by Professor Gantar during the Fall '08 term at FIU.

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Chapter 15 - Chapter15 SpecificImmunity 0...

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