Chapter 16

Chapter 16 - MCB 2000 - Exam 2 Notes Chapter 16 Disorders...

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MCB 2000 - Exam 2 Notes Chapter 16 Disorders in Immunity Immunopathology - the study of diseases associated with over-reactivity or under- reactivity for the immune system Allergies 0 •Sometimes body responds to antigens other than pathogenic microorganisms - this is hypersensitivity - allergy 1 •Antigens causing allergies are called allergens 0 –Exogenous: pollen, mold, dust mites, cat and dog antigens, insect venom, etc. 1 –Endogenous: self tissue (auto-immunities) 2 •Allergies occur in persons who have been sensitized (previously exposed) to some allergen 1 Types of Allergic Reactions 0 Type 1 - anaphylactic reactions (IgE) 0 –Initial encounter with an allergen (sensitizing dose) 0 Allergen is carried with lymphatics to lymph nodes - B cells are activated and proliferate into plasma cells 1 IgE is produced - binds to mast cells 0 Mast cells are located in the connective tissue throughout the body 1 No symptoms 1 –The 2nd encounter with allergen 0 When the allergen encounters two adjacent antibody molecules already attached to the surface of the mast cell, it will bridge over two antibodies 1 This will trigger the mast cell to release mediators (histamine, serotonin, leukortein) - deganualte causing allergy symptoms 0 targets of the chemical mediators include skin, upper respiratory tract, gastrointestinal tract, and conjutiva 1 Symptoms include 0 Rashes, itching, etc. 2 Histamine is the fastest acting mediator 0 Constrict smooth muscle of bronchi - labored breathing 1 Dilates blood vessels - hypotension, tachycardia, shock 2 Increases the permeability of blood vessels (swelling and redness) and mucus secretion (runny nose) 2 Diseases Associated with Type 1 Hypersensitivity 0 Hay fever
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This note was uploaded on 09/16/2011 for the course MCB 2000 taught by Professor Gantar during the Fall '08 term at FIU.

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Chapter 16 - MCB 2000 - Exam 2 Notes Chapter 16 Disorders...

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