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Unformatted text preview: 96 PRACTICAL ORGANIC CHEMISTRY OH OH O I I- H - I! (Ill) ^=* R - C - O E t =F=^ R - C - O E t 5=^ R - C - O E t 1 +O H H (IV) (V) (V I) A series of equilibria is thus established, the constituents of the mixture depen- ding on the local conditions. (2) The Fischer-Speier Method. In certain cases of esterification sul- phuric acid cannot be used. Thus if the alcohol or the organic acid is unsaturated, the sulphuric acid may add on at the unsaturated group. If the alcohol or the acid is aromatic in type, considerable sulphonation of the benzene ring may result. Finally, if an amino-acid, such as glycine or ammo- acetic acid, NH 2 CH 2 COOH, is to be esterified, the amino group would also undergo salt formation, and thus the hydrogen sulphate of aminoacetic ethyl ester, H 8 SO^NHaCH 2 COOC 2 Hj 1 , would result, and would be very difficult to isolate from the excess of sulphuric acid. These difficulties are overcome by the Fischer-Speier method, in which a mixture of the alcohol and the organic acid is...
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This note was uploaded on 09/19/2011 for the course CHM 2211 taught by Professor Castalleano during the Fall '06 term at University of Florida.
- Fall '06
- Organic chemistry