Unformatted text preview: PREPARATIONS i n therefore maintain the latter between 50° and 60° throughout the addition, cooling the flask occasionally in cold water if necessary. Finally heat the mixture on a boiling water-bath for 5 minutes, CH 3 COCl + HOC 6 H 4 COOH - CH 3 COOC 6 H 4 COOH + HCl Salicylic Acid Aspirin and then, after cooling in cold water, pour it in a thin stream into about 300 ml. of cold water, stirring the mixture vigorously meanwhile. The crude acetylsalicylic acid either solidifies at once, or separates as an oil which rapidly crystallises as the stirring proceeds. Filter the solid product at the pump, wash thoroughly with water and drain. Recrystallise from a mixture of equal volumes of water and acetic acid: yield, n g. (Alter- natively, press the crude product between several sheets of drying- paper until quite dry, and then recrystallise from benzene: a sticky product will result, however, if traces of water still remain.) The acetylsalicylic acid is obtained as colourless crystals, m.p.The acetylsalicylic acid is obtained as colourless crystals, m....
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- Fall '06
- Organic chemistry, Carboxylic acid, Sodium hydroxide, Salicylic acid, Acetic anhydride