ii6 PRACTICAL ORGANIC CHEMISTRY the acid itself. Thus acetyl chloride and sodium acetate readily interact with CH 3 CO Cl 4- Na GOCCH 8-^CH 3 CO-O COCH 3 + NaCl the formation of acetic anhydride. It should be emphasised that whereas the interaction of a sodium salt and an acid chloride is a convenient general laboratory method for preparing all classes of anhydrides, acetic anhydride is prepared on a large scale by other and cheaper methods. Industrial processes are based on reactions indicated by the equations: (1) CH 3 COONa + S + 6Cl t-> 4 (CH 3 CO) 8 O -f 6NaCl + Na 1 SO 4 (2) CH.: C : O + CH 3 COOH -> (CH 3 CO) 1 O ketene Required: Anhydrous sodium acetate, 21 g.; acetyl chloride, 15 ml. Place 2i g. (a 20% excess) of powdered anhydrous sodium acetate* in a ioo ml. round-bottomed flask fitted with a reflux water-condenser, and cool the flask in ice-water. Place 15 ml. (16-5 g.) of acetyl chloride in a dropping-funnel fitted into the top of the condenser by means of a grooved cork (
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This note was uploaded on 09/19/2011 for the course CHM 2211 taught by Professor Castalleano during the Fall '06 term at University of Florida.