Organic 2 Review Problem 378

Organic 2 Review Problem 378 - 362 PRACTICAL ORGANIC...

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362 PRACTICAL ORGANIC CHEMISTRY of the sodium salt of the corresponding acid, and also the free amine. If the latter is aromatic, it will be insoluble and can be extracted with ether from the cold hydrolysis mixture, and then identified (p, 347). If the amine is aliphatic, it will probably remain dissolved in the cold mixture: a portion of this mixture may then be shaken with benzoyl chloride (p. 243), and the benzoyl derivative of the amine thus isolated and identified. (C) N-Benzylamides. Amides readily react by interchange with R-CONH 2 + H 2 N-CH 2 C 6 H 5 -> R-CO-NH-CH 2 C 6 H 5 benzylamine to give benzylamides. Example. Heat together under reflux 0-5 g. of ammonium tartrate and 1-5 ml. of benzylamine for i hour. Shake with water to remove the excess of benzylamine and filter off the benzylamide. Recrystallise from ethanol; m.p. 199°. (M.ps., pp. 543-345O Urea. Prepare the nitrate or oxalate (see below). Thiourea.
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This note was uploaded on 09/19/2011 for the course CHM 2211 taught by Professor Castalleano during the Fall '06 term at University of Florida.

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