exam1 05 - NAME: _ MIDTERM EXAM I BIOLOGY 231 26 September...

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NAME: _________ ___ _________________ MIDTERM EXAM I BIOLOGY 231 26 September 2005 ________________________________________________________________________________ -1- GENERAL INSTRUCTIONS: 1. Answer all questions IN INK. 2. NO CALCULATORS. 3. Confine each answer to the BOX or SPACE provided. You are free to use the backs of the pages for scratch work, but ONLY what is written in the box or space will be graded! 4. SHOW YOUR WORK in all calculations. Be careful to use the right UNITS. 5. Make sure that your name is PRINTED LEGIBLY on EACH PAGE. 6. This exam consists of 7 questions on 14 pages and it is worth a total of 100 points. Information that may be useful: < For the reaction A + B <==> C + D, ) G = ) G o + RTln([C][D]/[A][B]) and RTln(X) = 5.7 kJ/mol @ log(X) < At equilibrium, ) G = 0 and ([C][D]/[A][B]) = K eq < log (10 X ) = X; 10 log(X) = X < surface of sphere = 4 B r 2 ; volume of sphere = 4/3 B r 3 ; area of circle = B r 2 < 1M = 10 3 mM = 10 6 : M ; 1 mole = 10 3 mmoles = 10 6 : moles < For an enzyme that obeys Michaelis-Menten kinetics, the relationship between V and [S] is: V = V MAX × [S] OR, ([S] + K M ) 1 = 1 + K M × 1 V V MAX V MAX [S] < An amino acid has the following structure (alpha-amino and alpha-carboxy groups shown in their charged form): < On this date in 1926, the Yankees dropped two games to the Browns in the shortest double-header in MLB history (55 min; the Yanks had clinched the pennant and might have tanked these games).
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NAME: _________ ___ _________________ MIDTERM EXAM I BIOLOGY 231 26 September 2005 ________________________________________________________________________________ -2- R groups of some amino acids, shown in their charged form, if relevant: ala (A): ser (S): glu (E): gly (G): lys (K): arg (R): val (V): tyr (Y): his (H): trp (W): leu (L): asp (D):
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NAME: _________ ___ _________________ MIDTERM EXAM I BIOLOGY 231 26 September 2005 ________________________________________________________________________________ -3- pK values of some amino acids amino acid pK of side chain or terminal group Alanine (ala or A) Uncharged Arginine (arg or R) 12.5 Asparagine (asn or N) Uncharged Aspartic acid (asp or D) 3.9 Cysteine (cys or C) 8.3 Glutamic acid (glu or E) 4.3 Glycine (gly or G) Uncharged Histidine (his or H) 6.0 Leucine (leu or L) Uncharged Lysine (lys or K) 10.8 Phenylalanine (phe or F) Uncharged Serine (ser or S) Uncharged Tyrosine (tyr or Y) 10.9 Tryptophan (trp or W) Uncharged Valine (val or V) Uncharged peptide N terminus 7.8 peptide C terminus 3.6
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NAME: _________ ___ _________________ MIDTERM EXAM I BIOLOGY 231 26 September 2005 ________________________________________________________________________________ -4- (1) Dengue is a mosquito-borne virus that causes dengue fever in tropical and sub-tropical regions, and studies are underway in many laboratories to identify ways to combat the disease. The Dengue Virus Envelope Protein, which is present on the surface of the virus, allows it to bind cell surface receptors and invade the cell. It is shown above in a
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exam1 05 - NAME: _ MIDTERM EXAM I BIOLOGY 231 26 September...

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