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06) 03 Sept 2010

06) 03 Sept 2010 - Nomenclature Protein linear polymer of...

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Nomenclature Protein – linear polymer of condensed amino acids Condensation – the removal of water to form a bond Hydrolysis – the addition of water to break a bond Residue – an amino acid incorporated into a protein Peptide bond – the amide bond formed between amino acids Polypeptide – short protein polymers, < 100 amino acid residues, > 100 residues is considered a protein Oligopeptide – short peptide < 10 (or 20) residues, can also use prefixes di-, tri-, tetra-, penta-peptide, etc.
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The ribosome, a massive RNA-protein complex, catalyzes the condensation of amino acids as part of the process known as translation. Proteases and peptidases are enzymes that hydrolyze the condensation product Ribosomes Proteases
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The pentapeptide is ser-gly-tyr-ala-leu or SGYAL Peptide bonds are amides, the polymer has n-1 peptide bonds in the backbone The first residues has a free amine group – the N terminus The last residue has a free carboxyl group – the C terminus By convention, we report sequences from N to C
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Amino acids can have multiple ionizable groups As residues, with exception of N and C, only side chains can have ionizable groups __peptide?
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