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13 24 Sept 2010 - Immunity Leukocytes white blood cells...

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Immunity Leukocytes – white blood cells Three fractions from low speed centrifugation of whole blood – erythrocytes, buffy coat, and serum Basophil, eosinophil, neutrophil (granulocytes) lymphocytes , macrophage , monocytes, dendridic cells (agranulocytes) Bone marrow hematopoietic stem cells Humoral immune system – extracellular immune reaction Cellular immune system – react with infected cells
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Lymphocytes – small amount in the circulatory system, mainly found in lymph system B lymphocytes (B cells – mature in bone) secrete antibodies (the main protein in humoral response) T lymphocytes (T cells – mature in thymus) display T cell receptors = antibody-like proteins on cell surface (the main protein in cellular response) T cell receptors on cytotoxic T cells (T C ) bind to infected cells Helper T cells (T H ) interact with active T C , attract macrophages, and signal proliferation Antibodies and T cell receptors have similar structure – the immunoglobin fold
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Immunoglobins B-cells secrete antibodies T-cells display T-cell receptors Antibodies and T-cell receptors have similar folds – the immunoglobin fold ( I g) Both proteins recognize antigens Antigens are displayed to T-cell by the major histocompatibility complex (MHC) The antigenic determinants (epitopes) are the small region on antigens that are bound by I
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