21 18 Oct 2010

21 18 Oct 2010 - Glycoproteins glycan component is smaller...

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Glycoproteins – glycan component is smaller and more diverse Protein – sugar linkage is either through Ser (O-acetal) or Asn (N-acetal) Glycomics – studies to catalog carbohydrate components of glycoproteins
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http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books 39 Bacterial and Viral Infections Victor Nizet and Jeffrey D. Esko 40 Parasitic Infections Richard Cummings and Salvatore Turco 41 Genetic Disorders of Glycan Degradation Hudson H. Freeze 42 Genetic Disorders of Glycosylation Hudson H. Freeze and Harry Schachter 43 Glycans in Acquired Human Diseases Ajit Varki and Hudson H. Freeze
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Lectins Lectins are proteins that bind sugars with high affinity Sialic acid is a common end group on the glycan chain Removal of the sialic acid end group reveals new binding site Erythrocytes are anuclear thus no apoptosis signal available Oxidized Hb aggregates a membrane glycoprotein Removal of sialic acid in the aggregate triggers antibody binding that signals removal by the spleen
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Many lectins have toxic effects Ricin is a potent toxin isolated from castor beans – elicits a severe immune response and inhibits ribosomes
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Selectins are plasma membrane receptors (lectins) that mediate cell-cell adhesion Human selectins are responsible for inflammation – the gathering of WBCs
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21 18 Oct 2010 - Glycoproteins glycan component is smaller...

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