27 01 Nov 2010

27 01 Nov 2010 - H1N1 What viruses cause flu? There are...

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H1N1 What viruses cause flu? There are three types of influenza viruses: A, B and C. Influenza A and B viruses cause seasonal epidemics of disease almost every winter in the United States. Influenza type C infections cause a mild respiratory illness and are not thought to cause epidemics. Influenza A viruses are divided into subtypes based on two proteins on the surface of the virus: the hemagglutinin (H) and the neuraminidase (N). There are 16 different hemagglutinin subtypes and 9 different neuraminidase subtypes, Influenza A viruses can be further broken down into different strains. The current subtypes of influenza A viruses found in people are A (H1N1) and A (H3N2). Influenza B viruses are not divided into subtypes. Influenza B viruses also can be further broken down into different strains. Influenza A (H1N1), A (H3N2), and influenza B strains are included in each year's influenza vaccine. Getting a flu vaccine can protect against influenza A and B viruses. The flu vaccine does not protect against influenza C viruses.
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Comparative Genomics = assign gene function through sequence relationship Synteny = chromosomal alignment of orthologs Proteomics = structure and function of gene products Protein function 1.) Phenotype = the resultant of the presence or absence of a protein in a cell 2.) Cellular function = the involvement of a protein in cellular processes 3.) Molecular function = the biochemical activity of the protein
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Differentiation is the selection of gene expression Proteomics is the analysis of gene expression through transcription or translation The presence of mature mRNA infers protein expression Genome sequences enable selective probes for each gene DNA microarrays are oligonucleotides adhered to a glass slide The oligonucleotide sequences are complimentary to the mRNA for each gene Photolithography is one method used to generate each specific sequence
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DNA chips can be used to probe differences between tissues, variations in tumors, cellular responses to change, etc For example, synchronized cells can released to S-phase The mRNA from pre and post released cells can be extracted and converted to cDNA using RT Add a green fluorescent tag to the
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This note was uploaded on 09/18/2011 for the course CHEM 3510 taught by Professor Mueser during the Spring '10 term at Toledo.

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27 01 Nov 2010 - H1N1 What viruses cause flu? There are...

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