6) Vertebrate Animal Models

6) Vertebrate Animal Models - 9/8/10 Developmental Biology...

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9/8/10 1 Developmental Biology BIOL 3090-001 Lecture 6) Patterning the Vertebrate Body: Animal Models Exam Thursday September 16 • Use the lecture slides as a guideline following up with your own notes and the textbook as required • Includes material up to and including next Tuesday ʼ s lecture – Chapters 1 - 3(?) • Exam format: – About 40 multiple choice questions – Some deFnitions – Some short answer questions
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9/8/10 2 Lecture Outline Life cycles: frog, fish, chicken (and mouse) Outlines of development Anatomical comparison Drosophila Vertebrates Segmentation genes Homeotic selector genes Wg and Hh Signaling Circuit en expressing cells secret Hh • Hh diffuses over the compartment boundary to activate and maintain wg expression in the adjacent cells • Wg feeds back to maintain hh and en expression in cells posterior
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9/8/10 3 Segment Identity is Specified by Hox Genes First evidence of genes that specify segment identity came from the observation of mutations that produced homeotic transformations Genes affected are called Hox genes: contain a homeobox Considered one of the fundamental defining features of multicellular animals All act in a similar way, specifying identity along the A/P axis Drosophila HOM Complexes Two Hox gene clusters in Drosophila Striking co-linearity between the spatial and temporal gene expression patterns and their order on the chromosome
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9/8/10 4 bithorax Complex Mutations • Flies with the bithorax mutation have the
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This note was uploaded on 09/18/2011 for the course BIOL 3090 taught by Professor Steven during the Spring '10 term at Toledo.

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6) Vertebrate Animal Models - 9/8/10 Developmental Biology...

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