7) Vertebrate Axis Formation 9.14

7) Vertebrate Axis Formation 9.14 - 9/13/10 Developmental...

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9/13/10 1 Developmental Biology BIOL 3090-001 Lecture 7) Patterning the Vertebrate Body: Axis Formation Lecture Outline Chicken development Mouse development The body axes: – Maternal factors – Wnt pathway specifies the future dorsal side – Patterning involving the Nieuwkoop center – Axes in chick and mouse – Left-right asymmetry
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9/13/10 2 Mouse Life Cycle • 9 week life cycle is relatively short for mammals • Egg is small and has no yolk Cleavage in the Mouse Embryo Relatively slow cell divisions: every 12 hours – Asynchronous After the eight cell stage compaction occurs to form the morula Blastocyst : Composed of inner cell mass and trophectoderm – ICM forms the embryo and extra-embryonic structures – Trophectoderm forms just extra-embryonic structures
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9/13/10 3 Cell Position and the Formation of the ICM • Outer blastomeres more often give rise to trophectoderm • Inner blastomeres often give rise to the ICM • Mouse embryo is highly regulative; cells determined only after 32-cell stage Post-Implantation Development ICM divides into two regions: epiblast and
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This note was uploaded on 09/18/2011 for the course BIOL 3090 taught by Professor Steven during the Spring '10 term at Toledo.

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7) Vertebrate Axis Formation 9.14 - 9/13/10 Developmental...

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