8) Vertebrate Germ Layers 9.21

8) Vertebrate Germ Layers 9.21 - 9/20/10 Developmental...

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9/20/10 1 Developmental Biology BIOL 3090-001 Lecture 8) Patterning the Vertebrate Body: Origin of the Germ Layers Lecture Outline Exam 1 Axes of the mouse embryo Left/right axis development Fate maps Molecular aspects of mesoderm induction – Four signals in Xenopus TGF- β signaling pathway
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9/20/10 2 Origin and Specification of the Germ Layers: Fate Mapping • What is the fate of that cell at later stages of development? Xenopus Blastula Fate Map
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9/20/10 3 Chick Embryo Fate Map • Mapping done after formation of primitive streak Mouse Embryo Fate Map • Again, mapping done after formation of primitive streak • Shown as if the “cup” was flattened
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9/20/10 4 Fate Maps Are In General Similar • Differences mainly due to the amount of yolk in egg • Future notochord is central • Neural ectoderm is adjacent to the presumptive notochord • Rest of ectoderm is usually anterior Early Vertebrate Embryos Have the Ability to Regulate • Potential for development is greater than fate map suggests – How do you study the state of determination of cells?
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8) Vertebrate Germ Layers 9.21 - 9/20/10 Developmental...

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