Dev Biol 10) Neural Induction 9.28 - 2 spp

Dev Biol 10) Neural Induction 9.28 - 2 spp - Developmental...

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9/27/10 1 Developmental Biology BIOL 3090-001 Lecture 10) Neural Induction Lecture Outline Role of Spemann’s organizer Molecule signals involved in induction Nervous system patterning by other regions Segmentation of the hindbrain: Ephrins and Hox genes Neural Induction Somite Formation c-hairy expression and somite fates Somite identity specified by Hox genes Somite dermatome, myotome and sclerotome Signals that determine somite fate
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9/27/10 2 Hox Genes Specify Somite Identity Homeodomain : A type of DNA binding domain Homeobox : DNA region that encodes the homeodomain Co-linearity • Four Hox complexes in mouse Overlapping Hox Gene Expression Specifies Identity • Gene activity can provide positional values or identities • Cell or tissue acquires a unique state related to its position at a given time –This determines its later development
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9/27/10 3 Mouse Hox Gene Expression • More 3’ gene is expressed further anterior • Most Hox genes express all the way posterior (border less well defined) Mouse Hox Gene Expression
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Dev Biol 10) Neural Induction 9.28 - 2 spp - Developmental...

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