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09 - Chapter 8 In vivo Buffering Regulating of acid CO2 is...

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11/12/09 Chapter 8 In vivo Buffering Regulating of acid CO 2 is rapidly released at the lungs H 2 O + CO 2 H 2 CO 3 Hydrogen carbonate is “blood acid” H 2 O + H 2 CO 3  H 3 O + + HCO 3 - K a = 4.3 x 10 -7 If CO 2 is present in its dissolved form, it can not be eliminated 15-20 moles of H 2 CO 3 produced per day if uncompensated blood pH drop precipitously H 2 O + H 2 CO 3  H 3 O + + HCO 3 - K a = 4.3 x 10 -7 Add H + Shift the equilibrium left More H 2 CO 3 Respiration is stimulated Expels CO 2 [ H 2 CO 3 ] decreases Pneumonia Expulsion of CO 2 is inhibited [ H 2 CO 3 ] increases & blood pH decreases Acidosis Harmful to Tissues We could have any concentration of acid and common ion expression that can be used to calculate pH of a buffered solution for any acid & ion concentration What one typically needs: 1) High buffer capacity—high concentration of both acid and its conjugate base 2) Concentration of [HA] and [A - ] are comparable 3) pK a of the weak acid is close to the desired pH
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