Midterm 2001. Bio 201

Midterm 2001. Bio 201 - BIOLOGY 177-201B Mid-Term 2001...

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BIOLOGY 177-201B Mid-Term 2001 Correct answers underlined 1. Nuclear-encoded proteins with no intrinsic amino acid signal sequence will a) not be fully translated b) exit the cell via constitutive secretion c) exit the cell via regulated secretion d) migrate to perioxomes e) are translated and remain in the cytoplasm 2. You would expect nuclear-encoded citrate synthase and other enzymes of the citric acid cycle to have a) stromal-import sequence b) stromal-import sequence and thylakoid-targeting sequence c) intermembrane space-targeting sequence d) matrix-targeting sequence e) chaperone-targeting sequence 3. The major function of the signal recognition particle (SRP) is to a) start translation b) stop translation c) start transfer d) stop transfer e) open translocon 4. In the Cisternal Maturation (or Cisternal Progression) model of transport through the Golgi, vesicles bud off a) medial golgi and travel by retrograde transport to cis golgi b) medial golgi and travel by retrograde transport to trans golgi c) cis golgi and travel by anterior transport to medial golgi d) ER and travel by anterior transport to medial golgi e) trans golgi and travel by anterior transport to cis golgi 5. A protein inserted into the RER membrane has the following topogenic features, arranged sequentially from the N terminus to the C terminus:
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signal sequence (or signal peptide), stop-transfer sequence, membrane-anchor sequence (or internal signal-anchor sequence), and stop-transfer sequence, with various lengths of hydrophilic amino acids in between these sequences. The protein will have a) 3 transmembrane segments with both termini in the cytoplasm b) 3 transmembrane segments with the N-terminus in the cytoplasm and C-terminus in the ER lumen c) 3 transmembrane segments with the N-terminus in the lumen of the ER and C-terminus in the cytoplasm d) 4 transmembrane segments with the N-terminus in the cytoplasm and C-terminus in the ER lumen e) 4 transmembrane segments with the N-terminus in the lumen of the ER and C-terminus in the cytoplasm 6. The enzyme protein disulphide isomerase (PDI) a) contains mannose 6-phosphate b) contains a KDEL sequence c) is a digestive enzyme secreted from pancreatic cells d) functions only at acid pH e) catalyses hydrolyis of the GTP in SAR-GTP binding proteins 7.Which of the following would NOT cause an increase in the LDL/HDL ratio?
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This note was uploaded on 09/18/2011 for the course SCIENCE biol 200 taught by Professor Bureau during the Spring '11 term at McGill.

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Midterm 2001. Bio 201 - BIOLOGY 177-201B Mid-Term 2001...

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