section 12 handout_answers

section 12 handout_answers - Bio1A Spring 2011 Discussion...

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Bio1A Spring 2011 Discussion Section Handout #12 Week of April 25, 2011 Stem Cells 1) Stem cells are cells that divide by _____ mitosis ______ to _______ self-renew _______ into two daughter stem cells, or after division one daughter cell retains its stem cells properties and the other daughter cell _______ differentiates ________ into different types of cells. 2) Match each example with one type of stem cell that characterizes it (totipotent, pluripotent, multipotent, unipotent) a. Bone marrow stem cells from adults Multipotent b. Trophoblast that forms the placenta Totipotent c. Muscle stem cells Unipotent d. Embryonic germ cells (precursors to spermatogonia or oogonia) Pluripotent 3) What is one technique that has worked for minimizing rejection of transplanted cells in primates? How does this technique work? What are two problems with this technique in humans? This technique is somatic cell nuclear transfer. It involves removing the nucleus from a primary oocyte and replacing it with a nucleus taken from a somatic cell (such as a skin cell) of the patient. The result is a diploid zygote that can be developed into a blastocyst in culture, and embryonic stem cells can be obtained from the blastocyst. Two problems in humans are aneuploidy (incorrect numbers of chromosomes in the cells) and amplification of mutations that are not major problems in single somatic cells, but may be harmful when replicated. 4) What are some approaches to stem cell therapy that avoid killing embryos to harvest stem cells? Removing a single cell from an 8-cell morula to develop embryonic stem cells Obtain stem cells from amniotic fluid Isolate pluripotent stem cells from the stem cells that produce spermatogonia “Reprogram” adult cells so they are again pluripotent like embryonic stem cells; mouse skin
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This note was uploaded on 09/20/2011 for the course CHEMISTRY 120 taught by Professor Head-gordon during the Spring '11 term at ASU.

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section 12 handout_answers - Bio1A Spring 2011 Discussion...

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