10-03 - BIO 5099: Molecular Biology for Computer Scientists...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
BIO 5099: Molecular Biology for Computer Scientists (et al) Lecture 12: More metabolism and a theory of the origin of life. http://compbio.uchsc.edu/hunter/bio5099 Larry.Hunter@uchsc.edu Respiration efficiency Respiration produces a net gain of as many as 38 moles of ATP per mole of glucose Glycolysis: 2 ATP + 2 NADH (no recycling in respiration) Oxidation of pyruvate: 2 NADH per glucose Krebs: 2 ATP + 6 NADH + 2 FADH per glucose Oxidative phosphorylation yields: 10 NADH ~30 ATP 2 FADH & ~4 ATP Uncertainties because proton motive force leaks a bit (and is used for other tasks). Respiration summary Cellular respiration consumes O 2 and produces CO 2 just like breathing. .. Respiration is the main catabolic pathway. Others which break down fats, starch, protein, etc. all eventually feed into glycolysis and/or Krebs. Only additional kind is neutralization of toxins (which also uses cytochromes, although different ones)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Glycogen Energy Storage Since ATP production is regulated to be near consumption levels, other molecules must be used to store energy Glycogen is a storage form of glucose. It is a large, branched polymer of glucose residues Glycogen is cleaved by glycogen phosphorylase to produce glucose-1-phosphate Glycogen metabolism Glycogen is phosphorylised rather than hydrolysed (to glucose), saving the energy required for the first glucose phosphorylation Synthesis of glycogen from glucose 6-phosphate is mediated by uridine diphosphate (a close relation of the nucleotide uracil) Costs 1 ATP per glucose 6-p to incorporate. Non- branching residues are phosphorylised at no energetic cost, so it takes only 1 of the 36 potential ATPs to store (<3%) a glucose.
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/20/2011 for the course CSC BIO 5099 taught by Professor Prof.larryhunter during the Fall '02 term at University of Colorado Denver.

Page1 / 7

10-03 - BIO 5099: Molecular Biology for Computer Scientists...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online