10-08 - BIO 5099: Molecular Biology for Computer Scientists...

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BIO 5099: Molecular Biology for Computer Scientists (et al) Lecture 13: DNA replication and repair http://compbio.uchsc.edu/hunter/bio5099 [email protected] Some comments on biochemistry The last two lectures (metabolism) have been hard. There are a lot of enzymes and substrates interacting in complex ways that can seem arbitrary and are hard to remember. You are not alone. No one is born with good intuitions about biochemistry. Try to hold onto the big concepts: Metabolism is the reshaping of food into offspring Energy metabolism exploits redox potential to form ATP Synthesis of biological molecules uses energetic intermediates as inputs. Life and Information Metabolism is the set of processes by which energy and matter are organized for survival and reproduction Living things also have functions that organize information for these purposes. The “blueprints” for metabolic enzymes and other biomolecules Control of when and how much to make of each The ability to pass on this information to offspring The ability to recognize and repair errors in this information
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Reproduction involves creating a copy of all genetic information to pass along to offspring Simplest in prokaryotes: binary fission (or, sometimes, budding) The single chromosome is duplicated The chromosome duplicates attach to opposite sides of the cell membrane The cell splits (cytokinesis). In budding, the pieces are of unequal size. Reproductive rate differences are exponential Species A reproduces at rate x (offspring/time) Species B reproduces at rate x What is the difference in population at time t? Initial populations equal P A (t 0 ) = P B (t 0 ) = p Population of A at time t, P A (t) = px t Population of B at time t, P B (t) = p( ε x) t P B (t) / P A (t) = ( ε x) t / x t = ε t Any difference in reproductive rate leads to an exponential difference in population over time! Binary fission and budding DNA replication is the key event. The most time-consuming aspect of reproduction
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This note was uploaded on 09/20/2011 for the course CSC BIO 5099 taught by Professor Prof.larryhunter during the Fall '02 term at University of Colorado Denver.

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10-08 - BIO 5099: Molecular Biology for Computer Scientists...

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