Chem 215 Exam 1 Topics

Chem 215 Exam 1 Topics - Samantha Bruni Topics on Chem 215...

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Samantha Bruni Topics on Chem 215 Exam 1 1. Alcohol Chemistry a. Alcohol + Acid = protonate alcohol and pop off water b. Alcohol + Base = deprotonate alcohol and form alkoxide (good nucleophile for SN2 or Base for E2 depending on other reagents) c. Intramolecular i. Formation of Ether : Deprotonate alcohol and form alkoxide which will do an intramolecular SN2 attach to form a ring ii. Formation of an Oxirane (special 3 sided cyclical ether) 1. Acidic Attack: will add to the most hindered side (the first protonation step causes the trivalent oxygen to move further away from this side and make it more electrophilic) 2. Basic Attack: will add to the less hindered side (the first attacking step will occur easier here) d. Alcohol to Alkyl Halide : New reagents SOCl 2 , SO 2 Cl 2 , PBr 3 , PI 3 i. You can also use Halogenic Acid like HBr to make the OH leave as water so that the Br will come in and satisfy the carbocation 2. Oxidation Reaction a. Assign Oxidation Numbers b. The oxidation mechanism changes the O-H group into O-LG so that an E2
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This note was uploaded on 09/21/2011 for the course CHEM 215 taught by Professor Koreeda during the Spring '07 term at University of Michigan.

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Chem 215 Exam 1 Topics - Samantha Bruni Topics on Chem 215...

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