g2.docx - Iron metabolism Iron has a pivotal role in many metabolic processes and the average adult contains 3\u20135 g of iron of which two\u2010thirds is in

g2.docx - Iron metabolism Iron has a pivotal role in many...

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Iron metabolism Iron has a pivotal role in many metabolic processes, and the average adult contains 3–5 g of iron, of which two thirds is in the oxygen carrying molecule haemoglobin. A normal Western diet provides about 15 mg of iron daily, of which 5–10% is absorbed (~1 mg), principally in the duodenum and upper jejunum, where the acidic conditions help the absorption of iron in the ferrous form. Absorption is helped by the presence of other reducing substances, such as hydrochloric acid and ascorbic acid. The body has the capacity to increase its iron absorption in the face of increased demand – for example, in pregnancy, lactation, growth spurts and iron deficiency (Box 1.1). Once absorbed from the bowel, iron is transported across the mucosal cell to the blood, where it is carried by the protein transferrin to developing red cells in the bone marrow. Iron stores comprise ferritin, a labile
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  • Spring '18
  • Mr. kanor
  • Hemoglobin, Iron deficiency anemia, Bone marrow

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