t2.docx - Introduction to the Physiology and Pathophysiology of the Hematopoietic System The reason why quantitative and qualitative diagnosis based on

t2.docx - Introduction to the Physiology and...

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Introduction to the Physiology and Pathophysiology of the Hematopoietic System The reason why quantitative and qualitative diagnosis based on the cellular components of the blood is so important is that blood cells are easily accessible indicators of disturbances in their organs of origin or degradation— which are much less easily accessible. Thus, disturbances in the erythrocyte, granulocyte, and thrombocyte series allow important conclusions to be drawn about bone marrow function, just as disturbances of the lymphatic cells indicate reactions or disease states of the specialized lymphopoietic organs (basically, the lymph nodes, spleen, and the diffuse lymphatic intestinal organ). Cell Systems All blood cells derive from a common stem cell. Under the influences of local and humoral factors, stem cells differentiate into different Fig. 1 Model of cell lineages! in hematopoiesis Physiology and Pathophysiology of Blood Cells Theml, Color Atlas of Hematology © 2004 Thieme All rights reserved. Usage subject to terms and conditions of license. 3 Omnipotent stem cells Eosinophils Granulopoiesis monopoiesis Monopoiesis Granulopoiesis Pluripotent myeloid stem cells Monoblasts Myeloblasts Promyelocytes Myelocytes Metamyelocytes Cells with band nuclei Neutrophilic granulocytes with segmented nuclei Monocytes Promonocytes Eosinophilic promyelocytes Eosinophilic segmented granulocytes Macrophages Erythropoiesis Proerythroblasts Erythroblasts Erythrocytes Thrombopoiesis
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  • Spring '18
  • Mr. kanor
  • Bone marrow, Cell nucleus, white blood cell

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